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Total 48 results found since Jan 2013.
Control groups for HIV prevention efficacy trials: what does the future hold?
Curr Opin HIV AIDS. 2023 Sep 12. doi: 10.1097/COH.0000000000000818. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Ending the HIV epidemic will require the development of additional effective immune-mediated and nonimmune-mediated means of HIV prevention. Evaluating novel interventions requires large, controlled trials demonstrating efficacy. Recent advances in the field of HIV prevention necessitate new approaches to efficacy trial design.RECENT FINDINGS: Three classes of efficacy trial designs are possible: standard of prevention-controlled trials, active-controlled trials, and active-controlled trials augmented with e...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Holly Janes Susan Buchbinder Source Type: research
An update on one-dose HPV vaccine studies, immunobridging and humoral immune responses - A meeting report
This report summarises the discussions and lessons learned on two topics: an update on one-dose HPV vaccination studies and humoral immune responses upon HPV vaccination. Long-term follow-up studies from Costa Rica (eleven years) and India (ten years) report stable levels of antibodies after a single HPV vaccination. High vaccine effectiveness against incident persistent HPV 16/18 infection was seen in India (95.4%, 85.0-99.9) ten years postvaccination and in Kenya (97.5%, 81.7-99.7) eighteen months postvaccination, an important observation in a setting with a higher HPV prevalence. The potential impact of HPV vaccination ...
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Dur-E-Nayab Waheed F Ricardo Burdier Carina Eklund Iacopo Baussano Filipe Cola ço Mariz Laura T éblick Nelly Mugo Deborah Watson-Jones Margaret Stanley Marc Baay Alex Vorsters Source Type: research
Data quality in an HIV vaccine efficacy clinical trial in South Africa: through natural disasters and with discipline
CONCLUSIONS: In the age of infectious and climate disaster risks, trials may benefit from simple study designs and trial-related documents. To optimise protocol adherence, sponsors and sites should consider ongoing training, and routinely review deviation reports with a view to adjusting processes. These data quality lessons may inform future trial design, training and implementation.TRIAL REGISTRATION: HVTN 702 was registered with the South African National Clinical Trials Register (DOH-27-0916-5327) and ClinicalTrials.gov ( NCT02968849 ).PMID:37355583 | DOI:10.1186/s12874-023-01967-9
Source: Cancer Control - June 24, 2023 Category: Cancer & Oncology Authors: Fatima Laher Mookho Malahleha Shelly Ramirez William Brumskine Kennedy Otwombe Zoe Moodie Mary Allen Source Type: research
Communication strategies to improve human papillomavirus (HPV) immunisation uptake among adolescents in sub-Saharan Africa: a systematic review and meta-analysis
Conclusion
HPV vaccine communication is critical in ensuring that the community understands the importance of vaccination. The most effective communication strategies included those which educate the population about the HPV vaccine, facilitate decision-making on vaccine uptake and community ownership of the vaccination process immunisation.
PROSPERO registration number
CRD42021243683.
Source: BMJ Open - April 3, 2023 Category: General Medicine Authors: Oketch, S. Y., Ochomo, E. O., Orwa, J. A., Mayieka, L. M., Abdullahi, L. H. Tags: Open access, Communication Source Type: research
A Perspective on Implementation Outcomes and Strategies to Promote the Uptake of COVID-19 Vaccines
Front Health Serv. 2022 May 20;2:897227. doi: 10.3389/frhs.2022.897227. eCollection 2022.ABSTRACTRecent articles have highlighted the importance of incorporating implementation science concepts into pandemic-related research. However, limited research has been documented to date regarding implementation outcomes that may be unique to COVID-19 vaccinations and how to utilize implementation strategies to address vaccine program-related implementation challenges. To address these gaps, we formed a global COVID-19 implementation workgroup of implementation scientists who met weekly for over a year to review the available liter...
Source: Cancer Control - March 17, 2023 Category: Cancer & Oncology Authors: Meagan Pilar A Rani Elwy Larissa Lushniak Grace Huang Gabriella M McLoughlin Cole Hooley Nisha Nadesan-Reddy Brittney Sandler Mosa Moshabela Olakunle Alonge Elvin Geng Enola Proctor Source Type: research
Weekly Overseas Health IT Links –1st October, 2022.
This article details information required for integration into EHRs to build personalized treatment plans and develop successful SDOH programs that provide resources and support for patients in need. In addition, successful SDOH programs implemented by Kaiser Permanente and Boston Medical Center showcase how supporting clinicians with real-time SDOH data can lead to patient-centric care. Create a 360-Degree Patient View Through TechnologyThe Office of the National Coordinator for Health Information Technology (ONC)indicatesthat the “collection, documentation, reporting, access, and use of SDOH data … can be used t...
Source: Australian Health Information Technology - October 1, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Design of Personalized Neoantigen RNA Vaccines Against Cancer Based on Next-Generation Sequencing Data
Methods Mol Biol. 2022;2547:165-185. doi: 10.1007/978-1-0716-2573-6_7.ABSTRACTThe good clinical results of immune checkpoint inhibitors (ICIs) in recent cancer therapy and the success of RNA vaccines against SARS-nCoV2 have provided important lessons to the scientific community. On the one hand, the efficacy of ICI depends on the number and immunogenicity of tumor neoantigens (TNAs) which unfortunately are not abundantly expressed in many cancer subtypes. On the other hand, novel RNA vaccines have significantly improved both the stability and immunogenicity of mRNA and its efficient delivery, this way overcoming past techn...
Source: Mol Biol Cell - September 6, 2022 Category: Molecular Biology Authors: Bego ña Alburquerque-González Mar ía Dolores López-Abellán Gin és Luengo-Gil Silvia Montoro-Garc ía Pablo Conesa-Zamora Source Type: research
Implementation During a Pandemic: Findings, Successes, and Lessons Learned from Community Grantees
J Cancer Educ. 2022 Sep 3. doi: 10.1007/s13187-022-02213-4. Online ahead of print.ABSTRACTFunding communities through mini-grant programs builds community capacity by fostering leadership among community members, developing expertise in implementing evidence-based practices, and increasing trust in partnerships. The South Carolina Cancer Prevention and Control Research Network (SC-CPCRN) implemented the Community Health Intervention Program (CHIP) mini-grants initiative to address cancer-related health disparities among high-risk populations in rural areas of the state. One community-based organization and one faith-based ...
Source: Cancer Control - September 2, 2022 Category: Cancer & Oncology Authors: Wilhelmenia Mathias Karen A Nichols Jewel Golden-Wright Ciaran M Fairman Tisha M Felder Lauren Workman Karen E Wickersham Kimberly J Flicker Jingxi Sheng Samuel B Noblet Swann Arp Adams Jan M Eberth Sue P Heiney Sara Wilcox James R H ébert Daniela B Frie Source Type: research
The Evolution of Medical Countermeasures for Ebola Virus Disease: Lessons Learned and Next Steps
Vaccines (Basel). 2022 Jul 29;10(8):1213. doi: 10.3390/vaccines10081213.ABSTRACTThe Ebola virus disease outbreak that occurred in Western Africa from 2013-2016, and subsequent smaller but increasingly frequent outbreaks of Ebola virus disease in recent years, spurred an unprecedented effort to develop and deploy effective vaccines, therapeutics, and diagnostics. This effort led to the U.S. regulatory approval of a diagnostic test, two vaccines, and two therapeutics for Ebola virus disease indications. Moreover, the establishment of fieldable diagnostic tests improved the speed with which patients can be diagnosed and publi...
Source: Cancer Control - August 26, 2022 Category: Cancer & Oncology Authors: Ian Crozier Kyla A Britson Daniel N Wolfe John D Klena Lisa E Hensley John S Lee Larry A Wolfraim Kimberly L Taylor Elizabeth S Higgs Joel M Montgomery Karen A Martins Source Type: research
Challenges and lessons from a school-based human papillomavirus (HPV) vaccination program for adolescent girls in a rural Nigerian community
CONCLUSION: An exploration of sociocultural perspectives and contextual realities is crucial to understanding the complexities of HPV vaccine introduction from the perspective of the target audience, and the local community. Strategies for introducing the HPV vaccine should address community concerns through effective communication, appropriate delivery, and targeted advocacy to make the vaccination program locally relevant. While school-based HPV immunization programs have been shown to be successful, adequate design, planning and monitoring is important. Additionally, considerations must be made to account for the high o...
Source: Rural Remote Health - August 24, 2022 Category: Rural Health Authors: Michael Egbon Tolulope Ojo Aminu Aliyu Zainab Shinkafi Bagudu Source Type: research
Nosocomial COVID-19 at a comprehensive cancer center during the first year of the pandemic: lessons learned
CONCLUSION: Our investigation of the cluster led to enhancement of our infection control measures. The implications of COVID-19 vaccination on infection control policies is still unclear and further studies are needed to delineate its impact on the transmission of COVID-19 in a hospital setting.PMID:35901993 | DOI:10.1016/j.ajic.2022.07.019
Source: Cancer Control - July 28, 2022 Category: Cancer & Oncology Authors: Fareed Khawaja Krithika Srinivasan Amy Spallone Adina Feldman Sherry Cantu Ella Ariza-Heredia Tanya Dvordak Amin Alousi Sairah Ahmed Marina George Elizabeth Frenzel Micah Bhatti Roy F Chemaly Source Type: research
Cancer vaccines: past, present and future; a review article
Discov Oncol. 2022 May 16;13(1):31. doi: 10.1007/s12672-022-00491-4.ABSTRACTImmunotherapy and vaccines have revolutionized disease treatment and prevention. Vaccines against infectious diseases have been in use for several decades. In contrast, only few cancer vaccines have been approved for human use. These include preventative vaccines against infectious agents associated with cancers, and therapeutic vaccines used as immunotherapy agents to treat cancers. Challenges in developing cancer vaccines include heterogeneity within and between cancer types, screening and identification of appropriate tumour-specific antigens, a...
Source: Ann Oncol - May 16, 2022 Category: Cancer & Oncology Authors: Eddie Grimmett Bayan Al-Share Mohamad Basem Alkassab Ryan Weng Zhou Advait Desai Mir Munir A Rahim Indryas Woldie Source Type: research
